Université Hassiba Benbouali de Chlef / Faculté de Technologie http://dspace.univ-chlef.dz/handle/123456789/1055 2026-04-05T22:05:05Z 2026-04-05T22:05:05Z SETRA, Ahmed Alaa Eddine http://dspace.univ-chlef.dz/handle/123456789/2276 2026-01-28T09:17:22Z 2024-01-01T00:00:00Z

Therapeutic Potential and Chemical Composition of Basil Essential Oil SETRA, Ahmed Alaa Eddine Basil essential oil, derived from the leaves of the Ocimum basilicum plant, has been widely recognized for its extensive therapeutic properties. This review highlights its primary bioactive compounds, such as linalool, eugenol, and methyl chavicol, which contribute to its pharmacological activities. The oil exhibits potent anti-inflammatory, antimicrobial, antioxidant, and analgesic properties, making it a valuable remedy in traditional and modern medicine. Studies have shown its efficacy in reducing symptoms of stress and anxiety due to its calming effects on the central nervous system. Additionally, basil essential oil demonstrates significant antibacterial and antifungal activities, offering potential in the treatment of infections and skin conditions. Its antioxidant properties help in combating oxidative stress, thus protecting cells from damage. Furthermore, the oil has been found to alleviate pain and inflammation, making it beneficial in managing conditions such as arthritis and muscle spasms. This comprehensive review underscores the therapeutic potential of basil essential oil. Further research is warranted to explore its full therapeutic potential and possible applications in integrative medicine. THESIS Presented for graduation from MASTER Speciality: Pharmaceutical Process Engineering

2024-01-01T00:00:00Z SEDDIK, Lamia http://dspace.univ-chlef.dz/handle/123456789/2275 2026-01-28T09:15:48Z 2024-01-01T00:00:00Z

Simulation of Continuous-Flow Pharmaceutical Production of Ibuprofen using ASPEN PLUS SEDDIK, Lamia Ibuprofen, a widely used therapeutic molecule, has been identified as an ideal candidate for continuous pharmaceutical manufacturing (CPM) due to its high global demand and extreme societal importance. The development of a continuous production system for ibuprofen aims to improve efficiency and reduce environmental impact. Based on the data obtained through laboratory experiments and parameters calculated in this work, an industrialscale production with a capacity of 200 tons/year of ibuprofen salt was simulated using Aspen Plus. This involves designing a steady-state process model and simulation for the continuous synthesis and purification of ibuprofen, utilizing plug flow reactors and a final separation step to achieve high API recovery Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Master in Process Engineering Speciality: Pharmaceutical Engineering

2024-01-01T00:00:00Z Aichouche, Hadjer http://dspace.univ-chlef.dz/handle/123456789/2274 2026-01-28T09:13:53Z 2024-01-01T00:00:00Z

Preparation and characterization of polymer film for the release of drugs Aichouche, Hadjer This work present a preparation and characterization of polymer films based on methylene blue, alginate, agar, starch, glycerol and citric acid for the local treatment of wounds. In the first part we addresse traditional and current wound and treatment issues, highlighting challenges in chronic wound treatment and advanced film systems for wound treatment. In the second part we intrdoduce polymer-based pharmaceutical films with methylene blue as effective alternatives for administering wound treatment. In the result we have films formation confirmed by IR spectroscopy(C=O, 1602cm-1 ), the crosslinking percentage (27⸓ for film 1, 80⸓for film2). For mthylene blue release, results indicate the controlled release with (8.9 10-3 mg/ml) at (240 min) and (8.6 10-3 mg/ml) at (150 min) for film1 and film2 respectively. Memory Presented for master graduation Field: Engineering Option: Pharmaceutical Process Engineering

2024-01-01T00:00:00Z MOSTEFAOUI, Hana SAIAH DJEBBOUR, Ikram http://dspace.univ-chlef.dz/handle/123456789/2273 2026-01-28T09:11:35Z 2024-01-01T00:00:00Z

Pharmacoinformatics-based identification process of phytochemicals against PARP-1 , HDACs and MDR as potential bioactive inhibitor compounds MOSTEFAOUI, Hana; SAIAH DJEBBOUR, Ikram Heart failure and Colon cancer diseases are among the most common diseases in the world while time. Treating these two diseases by targeting three specific proteins using molecules from different plants will be a promising potential process. The object of this study is to inhibit the PARP-1; HDACs and MDR receptors which are responsible for one of these two diseases respectively. After screening of more than 21 plants original from chlef State, Algeria. We selected the citrus peels ; Thymus vulgaris ; and Curcuma longa . The best ethanolic extracts yield is Citrus lemon peels (24.10%) and Thymus Vulgaris have the best inhibitory activity against Staphylococcus aureus ATCC6538 (Gram positive) with D=25mm. All the plants have antioxidant activity: IC50(Citrus)=0.198mg/ml , IC50( Curcuma )=0.206mg/ml, IC50( Thymus)=0.187mg/ml .GC-MS analysis indicated several components in extracts. The study conducted a pharmacoinformatics analysis “in silico” of 12compounds from 25 bioactive compounds. In silico studies reveal that the inhibitor ligand apigenine with PARP-1, forming 8 amino acid bonds with ∆G = -8.8 kcal/mol and thymonine interacts with HDAC1 forming 7 amino acid bonds with ∆G = -7.6 kcal/mol . We finished our work with a new formulation which is emulgel. Thesis Presented for graduation from MASTER2 Field: Process Engineering Option: Pharmaceutical Process Engineering

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