Résumé:
Heart failure and Colon cancer diseases are among the most common diseases in the world while
time. Treating these two diseases by targeting three specific proteins using molecules from different
plants will be a promising potential process. The object of this study is to inhibit the PARP-1; HDACs
and MDR receptors which are responsible for one of these two diseases respectively. After screening
of more than 21 plants original from chlef State, Algeria. We selected the citrus peels ; Thymus
vulgaris ; and Curcuma longa . The best ethanolic extracts yield is Citrus lemon peels (24.10%) and
Thymus Vulgaris have the best inhibitory activity against Staphylococcus aureus ATCC6538 (Gram
positive) with D=25mm. All the plants have antioxidant activity: IC50(Citrus)=0.198mg/ml , IC50(
Curcuma )=0.206mg/ml, IC50( Thymus)=0.187mg/ml .GC-MS analysis indicated several components
in extracts. The study conducted a pharmacoinformatics analysis “in silico” of 12compounds from 25
bioactive compounds. In silico studies reveal that the inhibitor ligand apigenine with PARP-1, forming
8 amino acid bonds with ∆G = -8.8 kcal/mol and thymonine interacts with HDAC1 forming 7 amino
acid bonds with ∆G = -7.6 kcal/mol . We finished our work with a new formulation which is emulgel.
