Résumé:
This work is part of an innovative approach aimed at developing drug delivery
systems based on natural polymers, with a view to sustainable biomedical solutions. The drug
delivery system is designed in the form of polymeric microparticles composed of chitosan
(Cs) and pectin (PEC). These natural biopolymers were selected for their complementary
properties and their ability to form stable microparticles through ionotropic gelation. Two
anti-inflammatory active ingredients were targeted for encapsulation: diclofenac sodium (DS),
a widely used synthetic molecule, and ginger essential oil (GEO), a natural compound known
for its antioxidant and anti-inflammatory properties.
The resulting microparticles exhibited diameters ranging from 200 to 600 µm, high
swelling capacity, and encapsulation efficiency exceeding 80%. In vitro release profiles
revealed a prolonged release, reaching 50 to 60% after 24 hours at pH 7.4. These results
confirm the potential of the Cs/PEC system as a promising platform for natural, targeted, and
controlled release therapeutic applications.
