Simulation of Continuous-Flow Pharmaceutical Production of Ibuprofen using ASPEN PLUS
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Date
2024
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Malika OUAGUED
Abstract
Ibuprofen, a widely used therapeutic molecule, has been identified as an ideal
candidate for continuous pharmaceutical manufacturing (CPM) due to its high global demand
and extreme societal importance. The development of a continuous production system for
ibuprofen aims to improve efficiency and reduce environmental impact. Based on the data
obtained through laboratory experiments and parameters calculated in this work, an industrialscale production with a capacity of 200 tons/year of ibuprofen salt was simulated using Aspen
Plus. This involves designing a steady-state process model and simulation for the continuous
synthesis and purification of ibuprofen, utilizing plug flow reactors and a final separation step
to achieve high API recovery
Description
Dissertation Submitted in Partial Fulfillment of the
Requirements for the Degree of Master in Process Engineering
Speciality: Pharmaceutical Engineering
Keywords
Ibuprofen, Continuous Manufacturing, Process modelling